A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Oncovin Online, Description, Chemistry, Ingredients - Vincristine Sulfate
Oncovin Online, Description, Chemistry, Ingredients - Vincristine Sulfate
DESCRIPTION
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WARNINGS
Caution- This preparation should be administered by individuals
experienced in the administration of vincristine sulfate injection.
It is extremely important that the intravenous needle or catheter
be properly positioned before any vincristine is injected. Leakage
into surrounding tissues during intravenous administration of vincristine
sulfate injection may cause considerable irritation. If extravasation
occurs, the injection should be discontinued immediately, and any
remaining portion of the dose should then be introduced into another
vein. Local injection of hyaluronidase and the application of moderate
heat to the area of leakage help disperse the drug and are thought
to minimize discomfort and the possibility of cellulitis.
FATAL IF GIVEN INTRATHECALLY. FOR INTRAVENOUS USE ONLY.
See WARNINGS section for
the treatment of patients given intrathecal vincristine sulfate
injection.
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Vincristine Sulfate Injection is the salt of an alkaloid obtained from
a common flowering herb, the periwinkle plant (Vinca rosea Linn).
Originally known as leurocristine it has also been referred to as LCR
and VCR. The molecular formula for vincristine sulfate is C46H56N4O10
• H2SO4. It has a molecular weight of 923.04.
Vincristine sulfate is a white to off-white powder. It is soluble in
methanol, freely soluble in water, but only slightly soluble in 95% ethanol.
In 98% ethanol, vincristine sulfate has an ultraviolet spectrum with maxima
at 221 nm (L+47,100).
Vincristine Sulfate Injection, USP is a sterile, preservative-free, single
use only solution available for intravenous use in 2 mL (1 mg and 2 mg)
vials. Each mL contains vincristine sulfate, 1 mg; mannitol, 100 mg; and
water for injection, q.s. Sulfuric acid or sodium hydroxide have been
added for pH control. The pH of Vincristine Sulfate Injection ranges from
4.0 to 5.0. At the time of manufacture, the air in the containers is replaced
by nitrogen.
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