Pitressin Side Effects, and Drug Interactions - Vasopressin

Pitressin Side Effects, and Drug Interactions - Vasopressin

SIDE EFFECTS

Local or systemic allergic reactions may occur in hypersensitive individuals. The following side effects have been reported following the administration of vasopressin.

Body as a Whole: anaphylaxia (cardiac arrest and/or shock) has been observed shortly after injection of vasopressin.

Cardiovascular: cardiac arrest, circumoral pallor, arrhythmias, decreased cardiac output, angina, myocardial ischemia, peripheral vasoconstruction and gangrene.

Gastrointestinal: abdominal cramps, nausea, vomiting, passage of gas.

Nervous System: tremor, vertigo, "pounding" in head.

Respiratory: bronchial constriction.

Skin and Appendages: sweating, urticaris, cutaneous gangrene.

DRUG INTERACTIONS

1) The following drugs may potentiate the antidiuretic effect of vasopressin when used concurrently: carbamazepine; chlorpropamide; clofibrate; urea; fludrocortisone; tricyclic antidepressants.

2) The following drugs may decrease the antidiuretic effect of vasopressin when used concurrently: demeclocyline; norepinephrine; lithium; heparin, alcohol.

3) Ganglionic blocking agents may produce a marked increase in sensitivity to the pressor effects of vasopressin.