A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Tonocard Overdose, Contraindications and Information - Tocainide HCl
Tonocard Overdose, Contraindications and Information - Tocainide HCl
OVERDOSE
The initial and most important signs and symptoms of. overdosage would
be expected to be related to the central nervous system. Other adverse
reactions, such as gastrointestinal disturbances, may follow. (See ADVERSE
REACTIONS.)
Should convulsions or cardiopulmonary depression or arrest develop, the
patency of the airway and adequacy of ventilation must be assured immediately.
Should convulsions persist, despite ventilatory therapy with oxygen, small
increments of anticonvulsive agents may be given intravenously. Examples
of such agents include a benzodiazepine (e.g., diazepam), an ultrashort-acting
barbiturate (e.g., thiopental or thiamylal), or a short-acting barbiturate
(e.g., pentobarbital or secobarbital).
The oral LD50 of tocainide was calculated to be about 800
mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths
were usually preceded by convulsions.
Studies in normal individuals to date indicate that tocainide has a hemodialysis
clearance approximately equivalent to its renal clearance.
CONTRAINDICATIONS
Patients who are hypersensitive to this product or to local anesthetics
of the amide type.
Patients with second or third degree atrioventricular block in the absence
of an artificial ventricular pacemaker.
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