A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Nebcin Side Effects, and Drug Interactions - Tobramycin
Nebcin Side Effects, and Drug Interactions - Tobramycin
SIDE EFFECTS
Neurotoxicity
Adverse effects on both the vestibular and auditory branches of the eighth
nerve have been noted, especially in patients receiving high doses or
prolonged therapy, in those given previous courses of therapy with an
ototoxin, and in cases of dehydration. Symptoms include dizziness, vertigo,
tinnitus, roaring in the ears, and hearing loss. Hearing loss is usually
irreversible and is manifested initially by diminution of high-tone acuity.
Tobramycin and gentamicin sulfates closely parallel each other in regard
to ototoxic potential.
Nephrotoxicity
Renal function changes, as shown by rising BUN, NPN, and serum creatinine
and by oliguria, cylindruria, and increased proteinuria, have been reported,
especially in patients with a history of renal impairment who are treated
for longer periods or with higher doses than those recommended. Adverse
renal effects can occur in patients with initially normal renal funotion.
Clinical studies and studies in experimental animals have been conducted
to compare the nephrotoxic potential of tobramycin and gentamicin. In
some of the clinical studies and in the animal studies, tobrarnycin caused
nephrotoxicity significantly less frequently than gentamicin. In some
other clinical studies, no significant difference in the incidence of
nephrotoxicity between tobramycin and gentamicin was found.
Other reported adverse reactions possibly related to Nebcin include anemia,
granulocytopenia, and thrombocytopenia; and fever, rash, exfoliative dermatitis,
itching, urticaria, nausea, vomiting, diarrhea, headache, lethargy, pain
at the injection site, mental confusion, and disorientation. Laboratory
abnormalities possibly related to Nebcin include increased serum transaminases
(AST, ALT); increased serum LDH and bilirubin; decreased serum calcium,
magnesium, sodium, and potassium; and leukopenia, leukocytosis, and eosinophilia.
DRUG INTERACTIONS
No information provided.
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