A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Timolol GFS Overdose, Contraindications and Information - Timolol Maleate
Timolol GFS Overdose, Contraindications and Information - Timolol Maleate
OVERDOSE
No data are available in regard to human overdose with, or
accidental oral ingestion of Timolol GFS. There have been reports of inadvertent
overdose with Timolol maleate ophthalmic solution resulting in systemic effects
similar to those seen with systemic beta-adrenergic blocking agents such as
dizziness, headache, shortness of breath, bradycardia, bronchospasm, and cardiac
arrest (see also ADVERSE REACTIONS).
Overdosage has been reported with Tablets BLOCADREN* (timolol
maleate tablets).A 30 year old female ingested 650 mg of BLOCADREN (maximum
recommended oral daily dose is 60 mg) and experienced second and third degree
heart block. She recovered without treatment but approximately two months later
developed irregular heartbeat, hypertension, dizziness, tinnitus, faintness,
increased pulse rate, and borderline first degree heart block.
An in vitro hemodialysis study, using 14C
timolol added to human plasma or whole blood, showed that timolol was readily
dialyzed from these fluids; however, a study of patients with renal failure
showed that timolol did not dialyze readily.
CONTRAINDICATIONS
Timolol GFS is contraindicated in patients with (1) bronchial
asthma; (2) a history of bronchial asthma; (3) severe chronic obstructive pulmonary
disease (see WARNINGS);
(4) sinus bradycardia; (5) second or third degree atrioventricular block; (6)
overt cardiac failure (see WARNINGS);
(7) cardiogenic shock; or (8) hypersensitivity to any component of this product.
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