A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Timolol GFS Online, Description, Chemistry, Ingredients - Timolol Maleate
Timolol GFS Online, Description, Chemistry, Ingredients - Timolol Maleate
DESCRIPTION
Timolol GFS (timolol maleate ophthalmic gel forming solution)
is a non-selective beta-adrenergic receptor blocking agent.Its chemical name
is (-)-1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol
maleate (1:1) (salt).Timolol maleate possesses an asymmetric carbon atom in
its structure and is provided as the levo-isomer.
The nominal optical rotation of timolol maleate is: [a]25º
in 0.1N HCl (C=5%) = -12.2º.
405 nm
Its molecular formula is C13H24N4O3S·C4H4O4 and its structual formula is:
Timolol maleate has a molecular weight of 432.50.It is a white,
odorless, crystalline powder which is soluble in water, methanol, and alcohol.
Timolol GFS is supplied as a sterile, isotonic, buffered, aqueous
solution of timolol maleate in two dosage strengths. Each mL of Timolol GFS
0.25% contains 2.5 mg of timolol (3.4 mg of timolol maleate).Each mL of Timolol
GFS 0.5% contains 5.0 mg of timolol (6.8 mg of timolol maleate).Inactive ingredients:
xanthan gum, tromethamine, boric acid,mannitol,polysorbate-80,and purified water.
Preservative: benzododecinium bromide 0.012%. DM-00 Xanthan gum is a purified
high molecular weight polysaccharide gum produced from the fermentation by bacterium
Xathomonas campestris. An aqueous solution of xanthan gum,in the presence
of tear protein (lysozyme),forms a gel.Upon contact with the precorneal tear
film,Timolol GFS forms a gel that is subsequently removed by the flow of tears.
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