A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Timolide Online, Description, Chemistry, Ingredients - Timolol Maleate-Hydrochlorothiazide
Timolide Online, Description, Chemistry, Ingredients - Timolol Maleate-Hydrochlorothiazide
TABLETS
TIMOLIDE®
(TIMOLOL MALEATE-HYDROCHLOROTHIAZIDE)
DESCRIPTION
TIMOLIDE* (Timolol Maleate-Hydrochlorothiazide) is for the
treatment of hyper-tension. It combines the antihyper-tensive activity of two
agents: a non-selective beta-adrenergic receptor blocking agent (timolol maleate)
and a diuretic (hydrochlorothiazide).
Timolol maleate is (S)-1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol
(Z )-2-butenedioate (1:1) salt. Its empirical formula is C13H24N4O3S_C4H4O4.
Timolol maleate has a molecular weight of 432.50. It is a white,
odorless, crystalline powder which is soluble in water, methanol, and alcohol.
Hydrochlorothiazide is 6-chloro-3,4-dihydro-2H-1,2,4-benzo-thiadiazine-7-sulfonamide
1,1-dioxide. Its empirical formula is C7H8ClN3O4S2
Hydrochlorothiazide has a molecular weight of 297.73. It is
a white, or practically white, crystalline powder which is slightly soluble
in water, but freely soluble in sodium hydroxide solution.
TIMOLIDE is supplied as tablets containing 10mg of timolol
maleate and 25 mg of hydrochlorothiazide for oral administration. Inactive ingredients
are cellulose, FD&C Blue 2, magnesium stearate, and starch.
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