A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Pentothal Side Effects, and Drug Interactions - Thiopental Sodium
Pentothal Side Effects, and Drug Interactions - Thiopental Sodium
SIDE EFFECTS
Pentothal
Adverse reactions include respiratory depression, myocardial depression,
cardiac arrhythmias, prolonged somnolence and recovery, sneezing, coughing,
bronchospasm, laryngospasm and shivering. Anaphylactic and anaphylactoid
reactions to Pentothal (Thiopental Sodium for Injection, USP) have been
reported. Symptoms, e.g., urticaria, bronchospasm, vasodilation and edema
should be managed by conventional means.
Rarely, immune hemolytic anemia with renal failure and radial nerve palsy
have been reported.
DRUG ABUSE AND DEPENDENCE
WARNING: MAY BE HABIT FORMING.
Thiopental sodium is classified as a Schedule III controlled substance.
Diluents in Pentothal® Kits
Ready-To-Mix Syringes and Vials
(For preparing solutions of Thiopental Sodium for Injection, USP)
Reactions which may occur because of the diluents, technique of preparation
or mixing, or administration of reconstituted solutions of Pentothal include
febrile response or infection at the site of injection, venous thrombosis
or phlebitis extending from the site of injection and extravasation.
If an adverse reaction does occur, discontinue the injection, evaluate
the patient, institute appropriate therapeutic countermeasures and save
the remainder of unused solution (or the used container or syringe) for
examination if deemed necessary.
DRUG ABUSE AND DEPENDENCE
None known.
DRUG INTERACTIONS
The following drug interactions have been reported with thiopental.
| Drug |
Effect |
| Probenecid |
Prolonged action of thiopental |
| Diazoxide |
Hypotension |
| Zimelidine |
Thiopental antagonism |
| Opioid analgesics |
Decreased antinociceptive action |
| Aminophylline |
Thiopental antagonism |
| Midazolam |
Synergism |
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