A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Anturane Warnings, Precautions, Pregnancy, Nursing, Abuse - Sulfinpyrazone
Anturane Warnings, Precautions, Pregnancy, Nursing, Abuse - Sulfinpyrazone
WARNINGS
Studies on the teratogenicity of pyrazole compounds in animals have yielded
inconclusive results. Up to the present time, however, there have been
no reported cases of human congenital malformation proved to be due to
the use of the drug.
It is suggested that Anturane be used with caution in pregnant women,
weighing the potential risks against the possible benefits.
PRECAUTIONS
As with all pyrazole compounds, patients receiving Anturane should be
kept under close medical supervision and periodic blood counts are recommended.
It may be administered with care to patients with a history of healed
peptic ulcer.
Recent reports have indicated that Anturane potentiates the action of
certain sulfonamides, such as sulfadiazine and sulfisoxazole. In addition,
other pyrazole compounds (phenylbutazone) have been observed to potentiate
the hypoglycemic sulfonylurea agents, as well as insulin. In view of these
observations, it is suggested that Anturane be used with caution in conjunction
with sulfa drugs, the sulfonylurea hypoglycemic agents and insulin.
Because Anturane is a potent uricosuric agent, it may precipitate urolithiasis
and renal colic, especially in the initial stages of therapy. For this
reason, an adequate fluid intake and alkalinization of the urine are recommended.
In cases with significant renal impairment, periodic assessment of renal
function is indicated. Occasional cases of renal failure have been reported;
but a cause-and-effect relationship has not always been clearly established.
Salicylates antagonize the uricosuric action of Anturane and for this
reason their concomitant use is contraindicated in gouty arthritis.
Anturane may accentuate the action of coumarin-type anticoagulants and
further depress prothrombin activity when these medications are employed
simultaneously.
Pediatric Use
Safety and effectiveness in pediatric patients have not been established.
NOTE: Anturane has minimal anti-inflammatory effect and is not
intended for the relief of an acute attack of gout.
In the initial stages of therapy, because of the marked ability of Anturane
to mobilize urates, acute attacks of gouty arthritis may be precipitated.
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