A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Slo-phyllin Side Effects, and Drug Interactions - Theophylline, Anhydrous
Slo-phyllin Side Effects, and Drug Interactions - Theophylline, Anhydrous
SIDE EFFECTS
The following adverse reactions have been observed, but there has not
been enough systematic collection of data to support an estimate of their
frequency. The most consistent adverse reactions are usually due to overdosage.
Gastrointestinal: nausea, vomiting, epigastric pain, hematemesis,
diarrhea.
Central Nervous System: headaches, irritability, restlessness,
insomnia, reflex hyperexcitability, muscle twitching, clonic and tonic
generalized convulsions.
Cardiovascular: palpitation, tachycardia, extrasystoles, flushing,
hypotension, circulatory failure, ventricular arrhythmias.
Respiratory: tachypnea.
Renal: potentiation of diuresis.
Other: alopecia, hyperglycemia, inappropriate ADH syndrome, rash.
DRUG INTERACTIONS
Drug-Drug Interactions: Toxic synergism with ephedrine has been
documented and may occur with some other sympathomimetic bronchodilators.
In addition, the following drug interactions have been demonstrated:
| Theophylline with Drug |
Effect |
| Allopurinol (high dose) |
Increased serum theophylline levels |
| Cimetidine |
Increased serum theophylline levels |
| Ciprofloxacin |
Increased serum theophylline levels |
| Erythromycin, Troleandomycin |
Increased serum theophylline levels |
| Lithium carbonate |
Increased renal excretion of lithium |
| Oral contraceptives |
Increased serum theophylline levels |
| Propranolol |
Increased serum theophylline levels |
| Phenytoin |
Decreased theophylline and phenytoin serum levels |
| Rifampin |
Decreased serum theophylline levels |
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