A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Silvadene Pharmacology, Pharmacokinetics, Studies, Metabolism - Silver Sulfadiazine
Silvadene Pharmacology, Pharmacokinetics, Studies, Metabolism - Silver Sulfadiazine
CLINICAL PHARMACOLOGY
Silver sulfadiazine
has broad antimicrobial
activity. It is bactericidal for many gram- negative
and gram-positive
bacteria as well as
being effective against yeast. Results from in vitro testing
are listed below.
Sufficient data have been obtained to demonstrate that silver
sulfadiazine will inhibit bacteria
that are resistant to other antimicrobial
agents and that the compound
is superior to sulfadiazine.
Studies utilizing radioactive micronized silver
sulfadiazine, electron
microscopy, and biochemical
techniques have revealed that the mechanism
of action of silver
sulfadiazine on
bacteria differs from silver
nitrate and sodium
sulfadiazine. Silver sulfadiazine acts only on the cell
membrane and cell
wall to produce its bactericidal
effect.
|
Results of In Vitro Testing With
Silver Sulfadiazine Cream 1% Concentration of Silver Sulfadiazine
Number of Sensitive Strains/ Total Number
of Strains Tested
|
| Genus & Species
|
50 µg/ mL
|
100 µg/ mL
|
| Pseudomonas aeruginosa |
130/ 130
|
130/ 130
|
|
Xanthomonas (Pseudomonas)
maltophilia
|
7/ 7
|
7/ 7
|
| Enterobacter
species |
48/ 50
|
50/ 50
|
| Enterobacter cloacae
|
24/ 24
|
24/ 24
|
| Kiebsiella species
|
53/ 54
|
54/ 54
|
| Escherichia coli
|
63/ 63
|
63/ 63
|
| Serratia species
|
27/ 28
|
28/ 28
|
| Proteus mirabilis
|
53/ 53
|
53/ 53
|
| Morganella morganii
|
10/ 10
|
10/ 10
|
| Providencia rettgeri
|
2/ 2
|
2/ 2
|
| Providencia species
|
1/ 1
|
1/ 1
|
| Proteus vulgaris
|
2/ 2
|
2/ 2
|
| Citrobacter
species |
10/ 10
|
10/ 10
|
| Acinetobacter
calcoaceticus |
10/ 11
|
11/ 11
|
| Staphylococcus
aureus |
100/ 101
|
100/ 101
|
| Staphylococcus
epidermidis |
51/ 51
|
51/ 51
|
| b
- Hemolytic Streptococcus
|
4/ 4
|
4/ 4
|
| Enterococcus species
|
52/ 53
|
53/ 53
|
| Corynebacterium
diphtheriae |
2/ 2
|
2/ 2
|
| Clostridium perfringens
|
0/ 2
|
2/ 2
|
| Candida albicans
|
43/ 50
|
50/ 50
|
Silver sulfadiazine
is not a carbonic anhydrase
inhibitor and may
be useful in situations where such
agents are contraindicated.
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