A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Sensipar Online, Description, Chemistry, Ingredients - Cinacalcet
Sensipar Online, Description, Chemistry, Ingredients - Cinacalcet
Sensipar (cinacalcet HCl) Tablets
DESCRIPTION
Sensipar™ (cinacalcet hydrochloride) is a calcimimetic
agent that increases the sensitivity of the calcium-sensing receptor to activation
by extracellular calcium. Its empirical formula is C22H22F3N·
HCl with a molecular weight of 393.9 g/mol (hydrochloride salt) and 357.4 g/mol
(free base). It has one chiral center having an R-absolute configuration. The
R-enantiomer is the more potent enantiomer and has been shown to be responsible
for pharmacodynamic activity.
Cinacalcet HCl is a white to off-white, crystalline solid that
is soluble in methanol or 95% ethanol and slightly soluble in water.
Sensipar™ tablets are formulated as light-green, film-coated,
oval-shaped tablets for oral administration in strengths of 30 mg, 60 mg, and
90 mg of cinacalcet HCl as the free base equivalent (33 mg, 66 mg, and 99 mg
as the hydrochloride salt, respectively). Cinacalcet HCl is described chemically
as N-[1-(R)-(-)-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-aminopropane
hydrochloride and has the following structual formula:
Inactive Ingredients: Sensipar™ tablets are comprised
of the active ingredient, and the following inactive ingredients: pre-gelatinized
starch, microcrystalline cellulose, povidone, crospovidone, colloidal silicon
dioxide, and magnesium stearate. Tablets are coated with color (Opadry®
II green) and clear film-coat (Opadry® clear), carnauba
wax, and Opacode® black ink.
top
