A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Sansert Online, Description, Chemistry, Ingredients - Methysergide maleate
Sansert Online, Description, Chemistry, Ingredients - Methysergide maleate
Sansert® (methysergide maleate) tablets
WARNING
Retroperitoneal Fibrosis, Pleuropulmonary Fibrosis and
Fibrotic Thickening of Cardiac Valves May Occur in Patients Receiving
Long-term Methysergide Maleate Therapy. Therefore, This Preparation Must
Be Reserved for Prophylaxis in Patients Whose Vascular Headaches Are Frequent
and/or Severe and Uncontrollable and Who Are Under Close Medical Supervision.
(See also WARNINGS section)
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DESCRIPTION
Sansert® (methysergide maleate) is a partially
synthetic compound structurally related to lysergic acid butanolamide, well-known
as methylergonovine in obstetrical practice as an oxytocic agent. Chemically,
methysergide maleate is designated as ergoline-8-carboxamide, 9,10-didehydro-N-[1-(hydroxymethyl)propyl]-1,6-dimethyl-,
(8ß)-, (Z)-2-butenedioate (1:1) (salt). The chemical structure is:
Methylation in the number 1 position of the ring structure
enormously enhances the antagonism to serotonin which is present to a much lesser
degree in the partially methylated compound (methylergonovine maleate) as well
as profoundly altering other pharmacologic properties.
Active Ingredient: methysergide maleate, USP.
Inactive Ingredients: acacia, carnauba wax, colloidal
silicon dioxide, FD&C Blue #1, FD&C Yellow #5, gelatin, lactose, malic
acid, povidone, sodium benzoate, starch (corn), stearic acid, sucrose, synthetic
black iron oxide, talc, and titanium dioxide.
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