A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Sandostatin Online, Description, Chemistry, Ingredients - Octreotide (Injection)
Sandostatin Online, Description, Chemistry, Ingredients - Octreotide (Injection)
DESCRIPTION
Sandostatin® (octreotide acetate) Injection, a cyclic
octapeptide prepared as a clear sterile solution of octreotide, acetate
salt, in a buffered lactic acid solution for administration by deep subcutaneous
(intrafat) or intravenous injection. Octreotide acetate, known chemically
as L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[2-hydroxy-1(
hydroxymethyl)propyl)-, cyclic( 2—> 7)-disulfide;[R-( R*,R*)] acetate
salt, is a long-acting octapeptide with pharmacologic actions mimicking
those of the natural hormone somatostatin.
Sandostatin® (octreotide acetate) Injection is available
as: sterile 1 mL ampuls in 3 strengths, containing 50, 100, or 500 mcg
octreotide (as acetate), and sterile 5 mL multi-dose vials in 2 strengths,
containing 200 and 1000 mcg/mL of octreotide (as acetate).
Each ampul also contains:
| lactic acid, USP |
|
3.4 mg |
| mannitol, USP |
|
45 mg |
| sodium bicarbonate, USP |
|
qs to pH 4.2 ± 0.3 |
| water for injection, USP |
|
qs to 1 mL |
Each mL of the multi-dose vials also contains:
| lactic acid, USP |
|
3.4 mg |
| mannitol, USP |
|
45 mg |
| phenol, USP |
|
5.0 mg |
| sodium bicarbonate, USP |
|
qs to pH 4.2 ± 0.3 |
| water for injection, USP |
|
qs to 1 mL |
Lactic acid and sodium bicarbonate are added to provide a buffered solution,
pH to 4.2 ± 0.3.
The molecular weight of octreotide acetate is 1019.3 (free peptide, C49H66N10O10S2).
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