A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Darvocet-N Side Effects, and Drug Interactions - Propoxyphene Napsylate and Acetaminophen
Darvocet-N Side Effects, and Drug Interactions - Propoxyphene Napsylate and Acetaminophen
SIDE EFFECTS
In a survey conducted in hospitalized patients, less than 1% of
patients taking propoxyphene hydrochloride
at recommended doses experienced side effects. The most frequently
reported were dizziness, sedation, nausea, and vomiting. Some of
these adverse reactions may be alleviated if the patient lies down.
Other adverse reactions include constipation, abdominal
pain, skin rashes, lightheadedness,
headache, weakness, euphoria, dysphoria, hallucinations, and minor
visual disturbances.
Liver dysfunction
has been reported in association
with both active components of propoxyphene napsylate and acetaminophen
tablets, USP. Propoxyphene therapy has been associated with abnormal
liver function
tests and more rarely with instances of reversible
jaundice (including
cholestatic jaundice). Hepatic necrosis
may result from acute
overdose of acetaminophen
(see OVERDOSAGE). In chronic
ethanol abusers, this
has been reported rarely with short-term use of acetaminophen
dosages of 2.5 to 10 g/day. Fatalities have occurred.
Renal papillary necrosis
may result from chronic
acetaminophen
use, particularly when the dosage
is greater than recommended and when combined with aspirin.
Subacute painful myopathy has occurred following chronic
propoxyphene overdosage.
DRUG ABUSE AND DEPENDENCE
Propoxyphene, when taken in higher-than-recommended doses over
long periods of time, can produce drug
dependence characterized
by psychic dependence
and, less frequently, physical
dependence and tolerance.
Propoxyphene will only partially suppress the withdrawal
syndrome in individuals
physically dependent on morphine
or other narcotics. The abuse
liability of propoxyphene is qualitatively similar to that of codeine
although quantitatively less. Propoxyphene should be prescribed
with the same degree
of caution appropriate to the use of codeine.
DRUG INTERACTIONS
The CNS-depressant effect
of propoxyphene is additive
with that of other CNS depressants, including alcohol.
As is the case with many medicinal
agents, propoxyphene may
the metabolism of a concomitantly administered drug. Should this occur,
the higher serum concentrations
of that drug may result in increased
pharmacologic or adverse effects of that drug. Such occurrences have been
reported when propoxyphene was administered to patients taking antidepressants,
anticonvulsants, or warfarin-like drugs. Severe neurologic signs, including
coma, have occurred with concurrent use of carbamazepine
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