A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Darvocet-N Online, Description, Chemistry, Ingredients - Propoxyphene Napsylate and Acetaminophen
Darvocet-N Online, Description, Chemistry, Ingredients - Propoxyphene Napsylate and Acetaminophen
DESCRIPTION
Propoxyphene napsylate, USP is an odorless, white, crystalline
powder with a bitter
taste. It is very slightly soluble
in water and soluble
in methanol, ethanol, chloroform, and acetone. Chemically, it is
(aS,1R)-a-[2-(Dimethylamino)-1-methylethyl]-a-phenylphenethyl
propionate compound
with 2-naphthalenesulfonic acid
(1:1) monohydrate. Its molecular weight
is 565.72.
Propoxyphene napsylate differs from propoxyphene hydrochloride
in that it allows more stable
liquid dosage
forms and tablet formulations.
Because of differences in molecular weight, a dose
of 100 mg (176.8 mcmol)
of propoxyphene napsylate is required to supply an amount of propoxyphene
equivalent to that present
in 65 mg (172.9 mcmol)
of propoxyphene hydrochloride.
Each Darvocet-N 50 tablet
contains 50 mg (88.4 mcmol)
propoxyphene napsylate and 325 mg
(2,150 mcmol) acetaminophen.
Each Darvocet-N 100 tablet
contains 100 mg (176.8 mcmol)
propoxyphene napsylate and 650 mg
(4,300 mcmol) acetaminophen.
Each tablet also contains
amberlite, cellulose, FD&C Yellow #6, magnesium stearate, stearic
acid, titanium dioxide, and
other inactive ingredients.
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