A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Prometh Dm Side Effects, and Drug Interactions - Promethazine and Dextromethorphan
Prometh Dm Side Effects, and Drug Interactions - Promethazine and Dextromethorphan
SIDE EFFECTS
Dextromethorphan
Dextromethorphan hydrobromide occasionally causes slight drowsiness,
dizziness, and gastrointestinal
disturbances.
Promethazine
Nervous System: Sedation, sleepiness, occasional
blurred vision, dryness of mouth, dizziness; rarely confusion, disorienta-
tion, and extrapyramidal
symptoms such as oculogyric
crisis, torticollis, and tongue protrusion
(usually in association
with parenteral injection
or excessive dosage).
Cardiovascular: Increased or decreased blood
pressure.
Dermatologic: Rash, rarely photosensitivity.
Hematologic: Rarely leukopenia, thrombocytopenia;
agranulocytosis (1 case).
Gastrointestinal: Nausea and vomiting.
DRUG ABUSE AND DEPENDENCE
According to the WHO Expert
Committee on Drug Dependence, dextromethorphan could produce very
slight psychic dependence
but no physical dependence.
DRUG INTERACTIONS
Hyperpyrexia, hypotension, and death
have been reported coincident with the coadministration
of monoamine oxidase
(MAO) inhibitors and products containing dextromethorphan. Thus,
concomitant administration
of promethazine with dextromethorphan
and MAO inhibitors should
be avoided (see CONTRAINDICATIONS).
The sedative action
of promethazine is additive
to the sedative effects
of other central nervous
system depressants, including
alcohol, narcotic analgesics, sedatives, hypnotics, tricyclic antidepressants,
and tranquilizers; therefore, these agents should be avoided or
administered in reduced dosage to patients receiving promethazine.
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