A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Matulane Side Effects, and Drug Interactions - Procarbazine- RxList Monographs
Matulane Side Effects, and Drug Interactions - Procarbazine- RxList Monographs
SIDE EFFECTS
Leukopenia, anemia and thrombopenia occur frequently. Nausea and vomiting
are the most commonly reported side effects.
Other adverse reactions are:
Hematologic: Pancytopenia; eosinophilia; hemolytic anemia;
bleeding tendencies such as petechiae, purpura, epistaxis and hemoptysis.
Gastrointestinal: Hepatic dysfunction, jaundice, stomatitis,
hematemesis, melena, diarrhea, dysphagia, anorexia, abdominal pain, constipation,
dry mouth.
Neurologic: Coma, convulsions, neuropathy, ataxia, paresthesia,
nystagmus, diminished reflexes, falling, foot drop, headache, dizziness,
unsteadiness.
Cardiovascular: Hypotension, tachycardia, syncope.
Ophthalmic: Retinal hemorrhage, papilledema, photophobia,
diplopia, inability to focus.
Respiratory: Pneumonitis, pleural effusion, cough.
Dermatologic: Herpes, dermatitis, pruritus, alopecia, hyperpigmentation,
rash, urticaria, flushing.
Allergic: Generalized allergic reactions.
Genitourinary: Hematuria, urinary frequency, nocturia.
Musculoskeletal: Pain, including myalgia and arthralgia;
tremors.
Psychiatric: Hallucinations, depression, apprehension,
nervousness, confusion, nightmares.
Endocrine: Gynecomastia in prepubertal and early pubertal
boys.
Miscellaneous: Intercurrent infections, hearing loss, pyrexia,
diaphoresis, lethargy, weakness, fatigue, edema, chills, insomnia, slurred
speech, hoarseness, drowsiness.
Second nonlymphoid malignancies, including acute myelocytic leukemia
and malignant myelosclerosis, and azoospermia have been reported in patients
with Hodgkin's disease treated with procarbazine in combination with other
chemotherapy and/or radiation.
DRUG INTERACTIONS
See WARNINGS section.
No cross-resistance with other chemotherapeutic agents, radiotherapy
or steroids has been demonstrated.
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