A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Procalamine Pharmacology, Pharmacokinetics, Studies, Metabolism - Amino Acid and Glycerin
Procalamine Pharmacology, Pharmacokinetics, Studies, Metabolism - Amino Acid and Glycerin
CLINICAL PHARMACOLOGY
ProcalAmine provides a physiological ratio of biologically
utilizable essential and nonessential amino acids, a nonprotein energy source,
and a balanced pattern of maintenance electrolytes.
The amino acids provide substrates for protein synthesis as
well as sparing body protein and muscle mass. Glycerin USP (glycerol), a utilizable
energy substrate, is also provided which serves to preserve body protein. Glycerol
participates as an active energy substrate through its phosphorylation to a-glycerophosphate
and subsequent conversion to dihydroxyacetone phosphate, one of the two key
trioses in the metabolism of glucose for energy generation.
The metabolism of glycerol has been investigated in both animals
and humans. The liver is chiefly responsible for the high potential of glycerol
utilization for gluconeogenesis, accounting for at least three-fourths of the
total capacity of the body to utilize glycerol. Further, the kidney accounts
for up to one-fifth of this total capacity. Among other kinds of cells and tissues
shown to utilize glycerol at various rates are the brain, intestine, muscle,
leukocytes, lungs and spermatozoa.
In a multicenter clinical study, mildly catabolic post-surgical
patients receiving ProcalAmine® (3% Amino Acid and 3% Glycerin Injection
with Electrolytes) showed a significant improvement in nitrogen balance when
compared with patients receiving isonitrogenous amino acids.
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