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Polymyxin B Side Effects, and Drug Interactions - Polymyxin B Sulfate

SIDE EFFECTS

See BOXED WARNING.

Nephrotoxic reactions:

Albuminuria

Cylindruria

Azotemia

Rising blood levels without any increase in dosage.

Neurotoxic reactions:

Facial flushing
Dizziness progressing to ataxia
Drowsiness
Peripheral paresthesias: circumoral and stocking-glove.
Apnea due to concurrent use of curariform muscle relaxants, other neurotoxic drugs, or inadvertent overdosage.
Signs of meningeal irritation with intrathecal administration, e.g. fever, headache, stiff neck and increased cell count and protein in cerebrospinal fluid.

Other reactions occasionally reported:

Drug fever

Urticarial rash

Pain (severe) at intramuscular injection sites

Thrombophlebitis at intravenous injection sites.

DRUG INTERACTIONS

No information provided.

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