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Antilirium Indications, Dosage, Storage, Stability - Physostigmine Salicylate (injection)

Antilirium Indications, Dosage, Storage, Stability - Physostigmine Salicylate (injection)

INDICATIONS

To reverse the effect upon the central nervous system, caused by clinical or toxic dosages of drugs capable of producing the anticholinergic syndrome.

DOSAGE AND ADMINISTRATION

Post Anesthesia Care: 0.5 to 1.0 mg intramuscularly or intravenously. INTRAVENOUS ADMINISTRATION SHOULD BE AT A SLOW CONTROLLED RATE OF NO MORE THAN 1 MG PER MINUTE. Dosage may be repeated at intervals of 10 to 30 minutes if desired patient response is not obtained.

Overdosage of Drugs that Cause Anticholinergia: 2.0 mg intramuscularly or INTRAVENOUSLY AT SLOW CONTROLLED RATE (SEE ABOVE). Dosage may be repeated if life threatening signs, such as arrhythmia, convulsions or comaoccurs.

Pediatric Dosage: Recommended dosage is 0.02 mg/kg, intramuscularly or by intravenous injection, no more than 0.5 mg per minute. If the toxic effects persist, and there is no sign of cholinergic effects, the dosage may be repeated at 5 to 10 minute intervals until a therapeutic effect is obtained or a maximum of 2 mg dosage is attained.

IN ALL CASES OF POISONING, THE USUAL SUPPORTIVE MEASURES SHOULD BE UNDERTAKEN.

HOW SUPPLIED

NDC 11098-510-02 2 mL
Ampoules packed 10 per box, 1 mg per mL.

STORAGE: Store at controlled room temperature 15° - 25° C (59°- 77° F).

CAUTION: Federal (USA) law prohibits dispensing without prescription.

SOME DRUGS WHICH PRODUCE THE ANTICHOLINERGIC SYNDROME

Amitriptyline, Amoxapine, Anisotropine, Atropine, Benztropine, Biperiden, Carbinoxamine, Clidinium, Cyclobenzaprine, Desipramine, Doxepin, Homatropine, Hyoscine, Hyoscyamine, Hyoscyamus, Imipramine, Lorazepam, Maprotiline, Mepenzolate, Nortriptyline, Propantheline, Protriptyline, Scopolamine, Trimipramine.

SOME PLANTS THAT PRODUCE THE ANTICHOLINERGIC SYNDROME

Black Henbane, Deadly Night Shade, Devil’s Apple, Jimson Weed, Loco Seeds or Weeds, Matrimony Vine, Night Blooming Jessamine, Stinkweed.

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