Neo-Synephrine Side Effects, and Drug Interactions - Phenylephrine (Injection)

Neo-Synephrine Side Effects, and Drug Interactions - Phenylephrine (Injection)

SIDE EFFECTS

Headache, reflex bradycardia, excitability, restlessness, and rarely arrhythmias.

DRUG INTERACTIONS

Vasopressors, particularly metaraminol, may cause serious cardiac arrhythmias during halothane anesthesia and therefore should be used only with great caution or not at all.

MAO Inhibitors

The pressor effect of sympathomimetic pressor amines is markedly potentiated in patients receiving monoamine oxidase inhibitors (MAOI). Therefore, when initiating pressor therapy in these patients, the initial dose should be small and used with due caution. The pressor response of adrenergic agents may also be potentiated by tricyclic antidepressants.