A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Regitine Overdose, Contraindications and Information - Phentolamine Mesylate
Regitine Overdose, Contraindications and Information - Phentolamine Mesylate
OVERDOSE
Acute Toxicity
No deaths due to acute
poisoning with phentolamine
have been reported.
Oral LD50's (mg/kg): mice, 1000; rats, 1250.
Signs and Symptoms
Overdosage with phentolamine is characterized chiefly by cardiovascular
disturbances, such as arrhythmias, tachycardia, hypotension, and
possibly shock. In addition,
the following might occur: excitation, headache, sweating, pupillary
contraction, visual disturbances;
nausea, vomiting, diarrhea; hypoglycemia.
Treatment
There is no specific
antidote. A decrease in blood
pressure to dangerous
levels or other evidence
of shocklike conditions should be treated vigorously and promptly.
The patient's legs should be kept raised
and a plasma expander
should be administered. If necessary, intravenous
infusion or norepinephrine,
titrated to maintain blood
pressure at the normotensive
level, and all available supportive measures should be included.
Epinephrine should not be used, since it may cause
a paradoxical reduction
in blood pressure.
CONTRAINDICATIONS
Myocardial infarction, history of myocardial
infarction, coronary insufficiency, angina, or other evidence
suggestive of coronary
artery disease; hypersensitivity to phentolamine or related compounds.
top
