Regitine Pharmacology, Pharmacokinetics, Studies, Metabolism - Phentolamine Mesylate

Regitine Pharmacology, Pharmacokinetics, Studies, Metabolism - Phentolamine Mesylate

CLINICAL PHARMACOLOGY

Phentolamine mesylate produces an alpha-adrenergic block of relatively short duration. It also has direct, but less marked, positive inotropic and chronotropic effects on cardiac muscle and vasodilator effects on vascular smooth muscle.

Phentolamine has a half-life in the blood of 19 minutes following intravenous administration. Approximately 13% of a single intravenous dose appears in the urine as unchanged drug.