Dibenzyline Side Effects, and Drug Interactions - Phenoxybenzamine

Dibenzyline Side Effects, and Drug Interactions - Phenoxybenzamine

SIDE EFFECTS

The following adverse reactions have been observed, but there are insufficient data to support an estimate of their frequency.

Autonomic Nervous System*: Postural hypotension, tachycardia, inhibition of ejaculation, nasal congestion, miosis.

Miscellaneous: Gastrointestinal irritation, drowsiness, fatigue.

*These so-called "side effects" are actually evidence of adrenergic blockade and vary according to the degree of blockade.

DRUG INTERACTIONS

Dibenzyline (phenoxybenzamine hydrochloride) may interact with compounds that stimulate both alpha- and beta- adrenergic receptors (i.e., epinephrine) to produce an exaggerated hypotensive response and tachycardia. (See WARNINGS.)

Dibenzyline blocks hyperthermia production by levarterenol, and blocks hypothermia production by reserpine.