A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Trilafon Indications, Dosage, Storage, Stability - Perphenazine
Trilafon Indications, Dosage, Storage, Stability - Perphenazine
INDICATIONS
Perphenazine is indicated for use in the management of the manifestations
of psychotic disorders; and for the control of severe nausea and vomiting
in adults.
Perphenazine has not been shown effective in the management of behavoral
complications in patients with mental retardation.
DOSAGE AND ADMINISTRATION
Dosage must be individualized and adjusted according to the severity
of the condition and the response obtained. As with all potent drugs,
the best dose is the lowest dose that will produce the desired clinical
effect. Since extrapyramidal symptoms increase in frequency and severity
with increased dosage, it is important to employ the lowest effective
dose. These symptoms have disappeared upon reduction of dosage, withdrawal
of the drug, or administration of an antiparkinsonian agent.
Prolonged administration of doses exceeding 24 mg daily should be reserved
for hospitalized patients or patients under continued observation for
early detection and management of adverse reactions. An antiparkinsonian
agent, such as trihexyphenidyl hydrochloride or benztropine mesylate,
is valuable in controlling drug-induced extrapyramidal symptoms.
Suggested dosages for various conditions follow:
Moderately disturbed nonhospitalized psychotic patients: 4 to 8 mg t.i.d.
initially; reduce as soon as possible to minimum effective dosage.
Hospitalized psychotic patients: 8 to 16 mg b.i.d. to q.i.d.; avoid dosages
in excess of 64 mg daily.
Severe nausea and vomiting in adults: 8 to 16 mg daily in divided doses;
24 mg occasionally may be necessary; early dosage reduction is desirable.
HOW SUPPLIED
Perphenazine tablets, USP are supplied as:
2 mg: round, film-coated white tablets, debossed GG 18 on one
side and plain on the reverse side, in bottles of 100 and 1000.
4 mg: round, film-coated white tablets, debossed GG 107 on one
side and plain on the reverse side, in bottles of 100, 500 and 1000.
8 mg: round, film-coated white tablets, debossed GG 108 on one
side and plain on the reverse side, in bottles of 100, 500 and 1000.
16 mg: round, film-coated white tablets, debossed GG 109 on one
side and plain on the reverse side, in bottles of 100 and 1000.
Store at controlled room temperature 15°-30°C (59°-86°F). Dispense in
a tight, light-resistant container.
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