A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Nebupent Side Effects, and Drug Interactions - Pentamidine Isethionate
Nebupent Side Effects, and Drug Interactions - Pentamidine Isethionate
SIDE EFFECTS
CAUTION: Fatalities due to severe hypotension,
hypoglycemia, acute pancreatitis
and cardiac arrhythmias
have been reported in patients treated with pentamidine
isethionate, both by the I.M.
and I.V. routes. The administration
of the drug should, therefore,
be limited to the patients in whom Pneumocystis carinii has
been demonstrated.
Of 424 patients treated with pentamidine
isethionate, 244 (57.5%) developed some adverse reaction. Most of
the patients had the acquired
immunodeficiency syndrome (AIDS). In
the following table, ''Severe'' refers to life- threatening reactions
or reactions that required immediate
corrective measures
and led to discontinuation of pentamidine
isethionate.
| Adverse Reactions
|
Number |
%
|
| Severe |
| Leukopenia (<
1000/ mm³) |
12
|
2.8
|
| Hypoglycemia (<
25 mg/dL) |
10
|
2.4
|
| Thrombocytopenia
(< 20,000/mm³) |
7
|
1.7
|
| Hypotension (<
60 mm Hg
systolic) |
4
|
0.9
|
|
Acute renal
failure
(serum creatinine
>6 mg/ dL)
|
2
|
0.5
|
| Hypocalcemia |
1
|
0.2
|
| Stevens- Johnson
syndrome |
1
|
0.2
|
| Ventricular tachycardia
|
1
|
0.2
|
|
Total number
of patients with
severe effects*
|
37
|
8.7
|
| Moderate |
|
Elevated serum
creatinine (2.4 to 6.0 mg/dL)
|
98
|
23.1
|
|
Sterile abscess,
pain, or induration
at the site
of I.M. injection
|
47
|
11.1
|
| Elevated liver
function tests
|
37
|
8.7
|
| Leukopenia |
32
|
7.5
|
| Nausea, anorexia
|
25
|
5.9
|
| Hypotension |
17
|
4.0
|
| Fever |
15
|
3.5
|
| Hypoglycemia |
15
|
3.5
|
| Rash |
14
|
3.3
|
| Bad taste
in mouth |
7
|
1.7
|
| Confusion/ hallucinations
|
7
|
1.7
|
| Anemia |
5
|
1.2
|
| Neuralgia |
4
|
0.9
|
| Thrombocytopenia
|
4
|
0.9
|
| Hyperkalemia |
3
|
0.7
|
| Phlebitis |
3
|
0.7
|
| Dizziness (without
hypotension) |
2
|
0.5
|
| Other moderate adverse
reactions** |
5
|
1.2
|
|
Total number
of patients with
moderate adverse reactions*
|
207
|
48.8
|
- * Patient total may not equal sum of reactions,
since some patients had more than one reaction.
- ** Each of the following moderate adverse reactions
was reported in one patient
: Hypocalcemia, abnormal
ST segment
of electrocardiogram, bronchospasm, diarrhea,
and hyperglycemia.
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