A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Pandel Pharmacology, Pharmacokinetics, Studies, Metabolism - Hydrocortisone Probutate Cream
Pandel Pharmacology, Pharmacokinetics, Studies, Metabolism - Hydrocortisone Probutate Cream
CLINICAL PHARMACOLOGY
Topical corticosteroids share anti-inflammatory, anti-pruritic and vasoconstrictive
actions. The mechanism of anti-inflammatory activity of the topical corticosteroids
is unclear. However, corticosteroids are thought to act by the induction
of phospholipase A2 inhibitory proteins, collectively called
lipocortins. It is postulated that these proteins control the biosynthesis
of potent mediators of inflammation such as prostaglandins and leukotrienes
by inhibiting the release of their common precursor arachidonic acid.
Arachidonic acid is released from membrane phospholipids by phospholipase
A 2 .
Pharmacokinetics
The extent of percutaneous absorption of topical corticosteroids is determined
by many factors, including the vehicle and the integrity of the epidermal
barrier. Use of occlusive dressings with hydrocortisone for up to 24 hours
has not been shown to increase penetration; however, occlusion of hydrocortisone
for 96 hours does markedly enhance penetration. Topical corticosteroids
can be absorbed from normal intact skin. Inflammation and/or other disease
processes in the skin increase percutaneous absorption.
Studies performed with Pandel® (hydrocortisone probutate cream)
Cream, 0.1% indicate that it is in the medium range of potency compared
with other topical corticosteroids.
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