A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Anadrol-50 Side Effects, and Drug Interactions - Oxymetholone
Anadrol-50 Side Effects, and Drug Interactions - Oxymetholone
SIDE EFFECTS
Hepatic: Cholestatic jaundice
with, rarely, hepatic
necrosis and death. Hepatocellular neoplasms and peliosis
hepatis have been reported in association
with long-term androgenic
anabolic steroid therapy
(see WARNINGS).
Genitourinary System:
- In Men:
- Prepubertal: Phallic enlargement
and increased frequency of erections.
- Postpubertal: Inhibition of testicular
function, testicular atrophy and oligospermia, impotence,
chronic priapism,
epididymitis, bladder irritability and decrease in seminal
volume.
- In Women:
- Clitoral enlargement, menstrual irregularities.
- In Both Sexes:
- Increased or decreased libido.
CNS: Excitation, insomnia.
Gastrointestinal: Nausea, vomiting,
diarrhea.
Hematologic: Bleeding in patients on concomitant
anticoagulant therapy, iron-deficiency anemia. Leukemia has been
observed in patients with aplastic anemia
treated with oxymetholone. The role, if any, of oxymetholone is
unclear because malignant
transformation
has been seen in blood
dyscrasias and leukemia
has been reported in patients with aplastic anemia
who have not been treated with oxymetholone.
Breast: Gynecomastia.
Larynx: Deepening of the voice
in women.
Hair: Hirsutism and male-pattern baldness
in women, male-pattern of hair
loss in postpubertal males.
Skin: Acne (especially in women and prepubertal boys).
Skeletal: Premature closure
of epiphyses in children (see PRECAUTIONS:
Pediatric Use), muscle
cramps.
Body as a Whole: Chills.
Fluid and Electrolytes: Edema, retention
of serum electrolytes
(sodium, chloride, potassium,
phosphate, calcium).
Metabolic/ Endocrine: Decreased glucose
tolerance (see PRECAUTIONS),
increased serum levels
of low-density lipoproteins and decreased levels of high-density
lipoproteins (see PRECAUTIONS:
Laboratory Tests), increased creatine
and creatinine excretion,
increased serum levels of creatinine
phosphokinase (CPK). Reversible changes in liver function tests
also occur, including increased bromsulphalein
(BSP) retention and increases in serum
bilirubin, glutamic
oxaloacetic transaminase
(SGOT), and alkaline
phosphatase.
DRUG ABUSE AND DEPENDENCE
Controlled Substance: ANADROL-50 is considered to be a controlled
substance and is listed in Schedule III.
DRUG INTERACTIONS
Anabolic steroids may increase sensitivity
to anticoagulants; therefore, dosage of an anticoagulant
may have to be decreased in order
to maintain the prothrombin
time at the desired therapeutic
level.
Drug/Laboratory Test Interferences
Therapy with androgenic
anabolic steroids may decrease levels of thyroxine-binding globulin
resulting in decreased total T4 serum
levels and increased resin uptake
of T3 and T4. Free thyroid
hormone levels remain
unchanged and there is no
clinical evidence
of thyroid dysfunction.
Altered tests usually persist for 2 to 3 weeks after stopping anabolic
therapy.
Anabolic steroids may cause
an increase in prothrombin
time.
Anabolic steroids have been shown to alter fasting
blood sugar
and glucose tolerance tests.
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