A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Omniscan Online, Description, Chemistry, Ingredients - Gadodiamide
Omniscan Online, Description, Chemistry, Ingredients - Gadodiamide
DESCRIPTION
OMNISCAN (gadodiamide) Injection is the formulation of the
gadolinium complex of diethylenetriamine pentaacetic acid bismethylamide, and
is an injectable, nonionic extracellular enhancing agent for magnetic resonance
imaging. OMNISCAN is to be administered by intravenous injection.
OMNISCAN is provided as a sterile, clear, colorless to slightly
yellow, aqueous solution. Each mL contains 287 mg gadodiamide, 12 mg caldiamide
sodium and water for injection. The pH is adjusted between 5.5 and 7.0 with
hydrochloric acid and/or sodium hydroxide. OMNISCAN contains no antimicrobial
preservative. OMNISCAN is a 0.5 mol/Lsolution of aqua[5,8-bis(carboxymethyl) -11-[2-(methylamino)-2-oxoethyl]- 3-oxo-2,5,8,11-tetraazatridecan-13- oato
(3-)-N5, N8, N11, O3, O5,
O8, O11, O13] gadolinium hydrate, with a molecular
weight of 573.66 (anhydrous), an empirical formula of C16H28GdN5O9•xH2O, and the following structual formula.
Pertinent physicochemical data for OMNISCAN are noted below:
|
PARAMETER
|
|
Osmolality (mOsmol/kg water)
|
@ 37°C
|
789
|
|
Viscosity (cP)
|
@ 20°C
|
2.0
|
| |
@ 37°C
|
1.4
|
|
Density (g/mL)
|
@ 25°C
|
1.14
|
|
Specific gravity
|
@ 25°C
|
1.15
|
|
OMNISCAN has an osmolality approximately 2.8 times that
of plasma at 37°C and is hypertonic under conditions of use.
|
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