A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Neomycin Sulfate Side Effects, and Drug Interactions - Neomycin Sulfate
Neomycin Sulfate Side Effects, and Drug Interactions - Neomycin Sulfate
SIDE EFFECTS
The most common adverse reactions to oral neomycin sulfate are nausea,
vomiting and diarrhea. The “Malabsorption Syndrome” characterized by increased
fecal fat, decreased serum carotene and fall in xylose absorption has
been reported with prolonged therapy. Nephrotoxicity, ototoxicity and
neuromuscular blockage have been reported (see BOXED
WARNINGS and PRECAUTIONS
sections).
DRUG INTERACTIONS
Caution should be taken in concurrent or serial use of other neurotoxic
and/ or nephrotoxic drugs because of possible enhancement of the nephrotoxicity
and/or ototoxicity of neomycin (see BOXED WARNINGS).
Caution should also be taken in concurrent or serial use of other aminoglycosides
and polymyxins because they may enhance neomycin’s nephrotoxicity and/or
ototoxicity and potentiate neomycin sulfate’s neuromuscular blocking effects.
Oral neomycin inhibits the gastrointestinal absorption of penicillin
V, oral vitamin B-12, methotrexate and 5-fluorouracil. The gastrointestinal
absorption of digoxin also appears to be inhibited. Therefore, digoxin
serum levels should be monitored.
Oral neomycin sulfate may enhance the effect of coumarin in anticoagulants
by decreasing vitamin K availability.
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