Narcan Overdose, Contraindications and Information - Naloxone

Narcan Overdose, Contraindications and Information - Naloxone

OVERDOSE

There is no clinical experience with naloxone hydrochloride overdosage in humans.

In the mouse and rat, the intravenous LD₅₀ is 150 ± 5 mg/kg and 109 ± 4 mg/kg, respectively. In acute subcutaneous toxicity studies in newborn rats, the LD₅₀ (95% CL) is 260 (228-296) mg/kg. Subcutaneous injection of 100 mg/kg/day in rats for 3 weeks produced only transient salivation and partial ptosis following injection; no toxic effects were seen at 10 mg/kg/day for 3 weeks.

CONTRAINDICATIONS

Naloxone Hydrochloride Injection is contraindicated in patients known to be hypersensitive to it.