A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Nubain Side Effects, and Drug Interactions - Nalbuphine hydrochloride
Nubain Side Effects, and Drug Interactions - Nalbuphine hydrochloride
SIDE EFFECTS
The most frequent adverse reaction in 1066 patients treated
in clinical studies with NUBAIN was sedation 381 (36%).
Less frequent reactions were: sweaty/clammy 99 (9%),
nausea/vomiting 68 (6%), dizziness/vertigo 58 (5%), dry mouth 44 (4%),
and headache 27 (3%).
Other adverse reactions which occurred (reported incidence
of 1% or less) were:
CNS Effects: Nervousness, depression, restlessness,
crying, euphoria, floating, hostility, unusual dreams, confusion, faintness,
hallucinations, dysphoria, feeling of heaviness, numbness, tingling, unreality.
The incidence of psychotomimetic effects, such as unreality, depersonalization,
delusions, dysphoria and hallucinations has been shown to be less than
that which occurs with pentazocine.
Cardiovascular: Hypertension, hypotension, bradycardia,
tachycardia.
Gastrointestinal: Cramps, dyspepsia, bitter taste.
Respiratory: Depression, dyspnea, asthma.
Dermatologic: Itching, burning, urticaria.
Miscellaneous: Speech difficulty, urinary urgency,
blurred vision, flushing and warmth.
Allergic Reactions: Anaphylactic/anaphylactoid
and other serious hypersensitivity reactions have been reported following
the use of nalbuphine and may require immediate, supportive medical treatment.
These reactions may include shock, respiratory distress, respiratory arrest,
bradycardia, cardiac arrest, hypotension, or laryngeal edema. Other allergic-type
reactions reported include stridor, bronchospasm, wheezing, edema, rash,
pruritus, nausea, vomiting, diaphoresis, weakness, and shakiness.
Post-marketing: Other reports include pulmonary
edema, agitation, seizures, and injection site reactions such as pain,
swelling, redness, burning, and hot sensations.
DRUG ABUSE AND DEPENDENCE
There have been reports of abuse and dependence associated
with NUBAIN among health care providers, patients and bodybuilders. There
have been reported instances of psychological and physical dependence
and tolerance in patients abusing NUBAIN. Individuals with a prior history
of opioid or other substance abuse or dependence may be at greater risk
in responding to reinforcing properties of NUBAIN.
Abrupt discontinuation of NUBAIN following prolonged
use has been followed by symptoms of opioid withdrawal, i.e., abdominal
cramps, nausea and vomiting, rhinorrhea, lacrimation, restlessness, anxiety,
elevated temperature and piloerection.
DRUG INTERACTIONS
No specific information available.
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