A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Mte 5 Warnings, Precautions, Pregnancy, Nursing, Abuse - Trace Metal-5 Combination
Mte 5 Warnings, Precautions, Pregnancy, Nursing, Abuse - Trace Metal-5 Combination
WARNINGS
Copper and Manganese are eliminated via the bile. In patients with
severe liver dysfunction and/or biliary tract obstruction, decreasing
or omitting copper and manganese supplements entirely may be necessary.
PRECAUTIONS
Before administering MULTITRACE™ - 5 CONCENTRATE
in TPN solutions, the physician must assess the metabolic requirements
for trace elements and disease state of the patient. Frequent determinations
of serum levels of the various trace elements are suggested as a guideline
for adjusting the dosage or completely omitting the solution. Zinc
is eliminated via the kidneys, therefore the possibility of Zinc retention
should be considered in patients with renal dysfunction. Copper
and Manganese are eliminated via the bile, therefore the possibility
of retention of these elements should be considered in patients with biliary
obstruction. Ancillary routes of Manganese excretion, however, include
pancreatic juice, or reabsorption into the lumen of duodenum, jejunum,
or ileum.
In assessing the contribution of Chromium supplements to maintenance
of normal glucose homeostasis, consideration should be given to the possibility
that the patient may be diabetic, in which case oral or intravenous antidiabetic
medication may be indicated.
As Selenium is eliminated in urine and feces, Selenium supplements
may be adjusted, reduced or omitted in renal disfunction and/or gastrointestinal
malfunction. In patients receiving blood transfusions, contribution from
such transfusions should also be considered. Frequent selenium plasma
level determinations are suggested as a guideline.
In animals, Selenium has been reported to enhance the action of Vitamin
E and decrease the toxicity of mercury, cadmium, and arsenic.
Pregnancy
Teratogenic Effects -Pregnancy Category C: Selenium at
high dose levels (15-30 mcg/egg) has been reported to have adverse
embryological effects among chickens. There are however no adequate
and well-controlled studies in pregnant women. MULTITRACE™ - 5 CONCENTRATE
should be used during pregnancy only if potential benefit justifies the
potential risk to the fetus.
Presence of Selenium in placenta and umbilical cord blood has been
reported in humans.
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