A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
M-M-R Ii Online, Description, Chemistry, Ingredients - Measles, Mumps, and Rubella Virus Vaccine Live
M-M-R Ii Online, Description, Chemistry, Ingredients - Measles, Mumps, and Rubella Virus Vaccine Live
DESCRIPTION
M-M-R* II (Measles, Mumps, and Rubella Virus Vaccine Live) is a live
virus vaccine for vaccination against measles (rubeola), mumps and rubella
(German measles).
M-M-R II is a sterile lyophilized preparation of (1) ATTENUVAX* (Measles
Virus Vaccine Live), a more attenuated line of measles virus, derived
from Enders’ attenuated Edmonston strain and propagated in chick embryo
cell culture; (2) MUMPSVAX* (Mumps Virus Vaccine Live), the Jeryl Lynn**
(B level) strain of mumps virus propagated in chick embryo cell culture;
and (3) MERUVAX* II (Rubella Virus Vaccine Live), the Wistar RA 27/3 strain
of live attenuated rubella virus propagated in WI-38 human diploid lung
fibroblasts.1,2
The growth medium for measles and mumps is Medium 199 (a buffered salt
solution containing vitamins and amino acids and supplemented with fetal
bovine serum) containing SPGA (sucrose, phosphate, glutamate, and human
albumin) as stabilizer and neomycin.
The growth medium for rubella is Minimum Essential Medium (MEM) [a buffered
salt solution containing vitamins and amino acids and supplemented with
fetal bovine serum] containing human serum albumin and neomycin. Sorbitol
and hydrolyzed gelatin stabilizer are added to the individual virus harvests.
The cells, virus pools, fetal bovine serum, and human albumin are all
screened for the absence of adventitious agents. Human albumin is processed
using the Cohn cold ethanol fractionation procedure.
The reconstituted vaccine is for subcutaneous administration. Each 0.5
mL dose contains not less than 1,000 TCID50 (tissue culture
infectious doses) of measles virus; 20,000 TCID50 of mumps
virus; and 1,000 TCID50 of rubella virus. Each dose of the
vaccine is calculated to contain sorbitol (14.5 mg), sodium phosphate,
sucrose (1.9 mg), sodium chloride, hydrolyzed gelatin (14.5 mg), human
albumin (0.3 mg), fetal bovine serum (< 1 ppm), other buffer and media
ingredients and approximately 25 mcg of neomycin. The product contains
no preservative.
Before reconstitution, the lyophilized vaccine is a light yellow compact
crystalline plug. M-M-R II, when reconstituted as directed, is clear yellow.
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