A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Tapazole Overdose, Contraindications and Information - Methimazole
Tapazole Overdose, Contraindications and Information - Methimazole
OVERDOSE
Signs and Symptoms
Symptoms may include nausea,
vomiting, epigastric
distress, headache, fever, joint
pain, pruritus,
and edema. Aplastic anemia
(pancytopenia) or agranulocytosis
may be manifested in hours to days. Less frequent events are hepatitis,
nephrotic syndrome,
exfoliative dermatitis,
neuropathies, and CNS stimulation
or depression. Although not well studied, methimazole-induced agranulocytosis
is generally associated with doses of 40 mg
or more in patients older than 40 years of age.
No information is available on the median
lethal dose
of the drug or the concentration
of methimazole in
biologic fluids associated
with toxicity and/or death.
Treatment
To obtain up-to-date information about the treatment
of overdose, a good resource is your certified Regional Poison Control
Center. Telephone numbers of certified poison
control centers are
listed in the Physicians’ Desk Reference (PDR). In
managing overdosage, consider the possibility of multiple
drug overdoses, interaction
among drugs, and unusual drug
kinetics in your patient.
Protect the patient’s airway
and support ventilation
and perfusion. Meticulously monitor
and maintain, within acceptable limits, the patient’s vital signs,
blood gases, serum
electrolytes, etc. The patient’s bone
marrow function should be monitored. Absorption of drugs from the
gastrointestinal tract may be decreased by giving activated charcoal,
which, in many cases, is more effective than emesis
or lavage; consider charcoal
instead of or in addition
to gastric emptying.
Repeated doses of charcoal
over time may hasten elimination
of some drugs that have been absorbed. Safeguard the patient’s airway
when employing gastric
emptying or charcoal.
Forced diuresis, peritoneal
dialysis, hemodialysis,
or charcoal hemoperfusion
have not been established as beneficial for an overdose
of methimazole.
CONTRAINDICATIONS
Tapazole is contraindicated in the presence of hypersensitivity
to the drug and in nursing
mothers because the drug
is excreted in milk.
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