A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Plan B Side Effects, and Drug Interactions - Levonorgestrel
Plan B Side Effects, and Drug Interactions - Levonorgestrel
SIDE EFFECTS
The most common adverse events in the clinical trial for women receiving
Plan B™ included nausea (23%), abdominal pain (18%), fatigue (17%), headache
(17%), and menstrual changes. The table below shows those adverse events
that occurred in £5% of Plan B™ users.
Table 3
Adverse Events in Less Than or Equal to 5% of Women, by % Frequency
|
Most Common
Adverse Events
|
Plan B™
Levonorgestrel
N = 977 (%)
|
| Nausea |
23.1
|
| Abdominal pain |
17.6
|
| Fatigue |
16.9
|
| Headache |
16.8
|
| Heavier menstrual bleeding |
13.8
|
| Lighter menstrual bleeding |
12.5
|
| Dizziness |
11.2
|
| Breast tenderness |
10.7
|
| Other complaints |
9.7
|
| Vomiting |
5.6
|
| Diarrhea |
5.0
|
Plan B™ demonstrated a superior safety profile over the Yuzpe regimen
for the following adverse events:
- Nausea: Occurred in 23% of women taking Plan B™ (compared to
50% with Yuzpe)
- Vomiting: Occurred in 6% of women taking Plan B™ (compared
to 19% with Yuzpe)
DRUG ABUSE AND DEPENDENCE
There is no information about dependence associated with the use of Plan
B™.
DRUG INTERACTIONS
Theoretically, the effectiveness of low-dose progestin-only pills is
reduced by hepatic enzyme-inducing drugs such as the anticonvulsants phenytoin,
carbamazepine, and barbiturates, and the antituberculosis drug rifampin.
No significant interaction has been found with broad-spectrum antibiotics.
It is not known whether the efficacy of Plan B™ would be affected by these
or any other medications.
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