A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Acular Online, Description, Chemistry, Ingredients - Ketorolac tromethamine
Acular Online, Description, Chemistry, Ingredients - Ketorolac tromethamine
ACULAR® (ketorolac tromethamine ophthalmic solution)
0.5% Sterile
DESCRIPTION
ACULAR® (ketorolac
tromethamine ophthalmic solution) is a member of the pyrrolo-pyrrole group
of nonsteroidal anti-inflammatory drugs (NSAIDs) for ophthalmic use. Its
chemical name is (±)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic
acid, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1) and it
has the following structure:
ACULAR® ophthalmic solution is supplied
as a sterile isotonic aqueous 0.5% solution, with a pH of 7.4. ACULAR®
ophthalmic solution is a racemic mixture of R-(+) and S-(-)- ketorolac
tromethamine. Ketorolac tromethamine may exist in three crystal forms. All forms
are equally soluble in water. The pKa of ketorolac is 3.5. This white to off-white
crystalline substance discolors on prolonged exposure to light. The molecular
weight of ketorolac tromethamine is 376. 41. The osmolality of ACULAR®
ophthalmic solution is 290 mOsml/kg. Each mL of ACULAR® ophthalmic
solution contains:
Active: ketorolac tromethamine 0.5%.
Preservative: benzalkonium chloride 0.01%.
Inactives: edetate disodium 0.1%; octoxynol 40; purified
water; sodium chloride; and hydrochloric acid and/or sodium hydroxide to adjust
the pH.
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