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Isuprel Side Effects, and Drug Interactions - Isoproterenol

SIDE EFFECTS

The following reactions to isoproterenol hydrochloride injection have been reported:

CNS: Nervousness, headache, dizziness.

Cardiovascular: Tachycardia, palpitations, angina, Adams- Stokes attacks, pulmonary edema, hypertension, hypotension, ventricular arrhythmias, tachyarrhythmias.

In a few patients, presumably with organic disease of the AV node and its branches, isoproterenol hydrochloride injection has been reported to precipitate Adams- Stokes seizures during normal sinus rhythm or transient heart block.

Other: Flushing of the skin, sweating, mild tremors, weakness.

DRUG INTERACTIONS

Isoproterenol hydrochloride injection and epinephrine should not be administered simultaneously because both drugs are direct cardiac stimulants and their combined effects may induce serious arrhythmias. The drugs may, however, be administered alternately provided a proper interval has elapsed between doses.

ISUPREL should be used with caution, if at all, when potent inhalational anesthetics such as halothane are employed because of potential to sensitize the myocardium to effects of sympathomimetic amines.

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