A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Invanz Overdose, Contraindications and Information - Ertapenem
Invanz Overdose, Contraindications and Information - Ertapenem
OVERDOSE
No specific information is available on the treatment of overdosage
with INVANZ. Intentional overdosing of INVANZ is unlikely. Intravenous administration
of INVANZ at a dose of 2 g over 30 min or 3 g over 1-2h in healthy volunteers
resulted in an increased incidence of nausea. In clinical studies, inadvertent
administration of three 1 g doses of INVANZ in a 24 hour period resulted in
diarrhea and transient dizziness in one patient. In the event of an overdose,
INVANZ should be discontinued and general supportive treatment given until renal
elimination takes place. INVANZ can be removed by hemodialysis; the plasma clearance
of the total fraction of ertapenem was increased 30% in subjects with end-stage
renal insufficiency when hemodialysis (4 hour session) was performed immediately
following administration. However, no information is available on the use of
hemodialysis to treat overdosage.
CONTRAINDICATIONS
INVANZ is contraindicated in patients with known hypersensitivity
to any component of this product or to other drugs in the same class or in patients
who have demonstrated anaphylactic reactions to beta-lactams. Due to the use
of lidocaine HCl as a diluent, INVANZ administered intramuscularly is contraindicated
in patients with a known hypersensitivity to local anesthetics of the amide
type. (Refer to the prescribing information for lidocaine HCl.)
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