A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Invanz Online, Description, Chemistry, Ingredients - Ertapenem
Invanz Online, Description, Chemistry, Ingredients - Ertapenem
DESCRIPTION
INVANZ(Ertapenem for Injection) is a sterile,
synthetic, parenteral, 1-b methyl-carbapenem
that is structurally related to beta-lactam antibiotics.
Chemically, INVANZ is described as [4R [3(3S*,5S*),4a,5b,6b(R*)]]-3-[[5-[[(3-carboxyphenyl)amino]carbonyl]- 3-pyrrolidinyl]thio]-6-(1-hydroxyethyl)-4-methyl- 7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2- carboxylic
acid monosodium salt. Its molecular weight is 497.50. The empirical formula
is C22H24N3O7SNa
Ertapenem sodium is a white to off-white hygroscopic, weakly
crystalline powder. It is soluble in water and 0.9% sodium chloride solution,
practically insoluble in ethanol, and insoluble in isopropyl acetate and tetrahydrofuran.
INVANZ is supplied as sterile lyophilized powder for intravenous
infusion after reconstitution with appropriate diluent (see DOSAGE
AND ADMINISTRATION, PREPARATION OF SOLUTION) and transfer to 50
mL 0.9% Sodium Chloride Injection or for intramuscular injection following reconstitution
with 1% lidocaine hydrochloride. Each vial contains 1.046 grams ertapenem sodium,
equivalent to 1 gram ertapenem. The sodium content is approximately 137 mg (approximately
6.0 mEq).
Each vial of INVANZ contains the following inactive ingredients:
175 mg sodium bicarbonate and sodium hydroxide to adjust pH to 7.5.
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