A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Remicade Online, Description, Chemistry, Ingredients - Infliximab
Remicade Online, Description, Chemistry, Ingredients - Infliximab
Remicade® INFLIXIMAB RECOMBINANT
WARNING
RISK OF INFECTIONS
TUBERCULOSIS (FREQUENTLY DISSEMINATED OR EXTRAPULMONARY
AT CLINICAL PRESENTATION), INVASIVE FUNGAL INFECTIONS, AND OTHER OPPORTUNISTIC
INFECTIONS, HAVE BEEN OBSERVED IN PATIENTS RECEIVING REMICADE. SOME OF
THESE INFECTIONS HAVE BEEN FATAL (SEE WARNINGS).
PATIENTS SHOULD BE EVALUATED FOR LATENT TUBERCULOSIS INFECTION WITH A
TUBERCULIN SKIN TEST.1 TREATMENT OF LATENT TUBERCULOSIS INFECTION
SHOULD BE INITIATED PRIOR TO THERAPY WITH REMICADE.
|
DESCRIPTION
REMICADE is a chimeric IgG1k monoclonal
antibody with an approximate molecular weight of 149,100 daltons. It is composed
of human constant and murine variable regions. Infliximab binds specifically
to human tumor necrosis factor alpha (TNFa) with
an association constant of 1010 M-1. Infliximab is produced
by a recombinant cell line cultured by continuous perfusion and is purified
by a series of steps that includes measures to inactivate and remove viruses.
REMICADE is supplied as a sterile, white, lyophilized powder
for intravenous infusion. Following reconstitution with 10 mL of Sterile Water
for Injection, USP, the resulting pH is approximately 7.2. Each single-use vial
contains 100 mg infliximab, 500 mg sucrose, 0.5 mg polysorbate 80, 2.2 mg monobasic
sodium phosphate, monohydrate, and 6.1 mg dibasic sodium phosphate, dihydrate.
No preservatives are present.
top
