Eldopaque Pharmacology, Pharmacokinetics, Studies, Metabolism - Hydroquinone (4% Cream)

Eldopaque Pharmacology, Pharmacokinetics, Studies, Metabolism - Hydroquinone (4% Cream)

CLINICAL PHARMACOLOGY

Topical application of hydroquinone produces a reversible depigmentation of the skin by inhibition of the enzymatic oxidation of tyrosine to 3,4-dihydroxyphenylalanine (dopa) (Denton, C. et al, 1952) ¹ and suppression of other melanocyte metabolic processes (Jimbow, K. et al, 1974) ².

Exposure to sunlight or ultraviolet light will cause repigmentation which may be prevented by the broad spectrum sunscreen agents contained in Solaquin Forte (Parrish, J. A. et al, 1978) ³.