A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Tenex Overdose, Contraindications and Information - Guanfacine
Tenex Overdose, Contraindications and Information - Guanfacine
OVERDOSE
Signs and Symptoms
Drowsiness, lethargy, bradycardia
and hypotension
have been observed following overdose
with guanfacine.
A 25-year-old female
intentionally ingested 60 mg. She presented with severe drowsiness
and bradycardia
of 45 beats/minute. Gastric lavage
was performed and an infusion
of isoproterenol (0.8 mg
in 12 hours) was administered. She recovered quickly and without
sequelae .
A 28-year-old female
who ingested 30-40mg developed only lethargy, was treated with activated
charcoal and a cathartic,
was monitored for 24 hours, and was discharged in good health
.
A 2-year-old male weighing
12kg, who ingested up to 4mg of guanfacine, developed lethargy.
Gastric lavage (followed
by activated charcoal
and sorbitol slurry via
NG tube) removed some tablet
fragments within 2 hours after ingestion, and vital
signs were normal. During 24-hours observation in ICU, systolic
pressure was 58 and
heart rate/U at 16 hours
post-ingestion. No intervention
was required, and child
was discharged fully recovered the next day.
Treatment of OVERDOSE
Gastric lavage and supportive
therapy as appropriate. Guanfacine is not dialyzable
in clinically significant
amounts (2.4%) .
CONTRAINDICATIONS
Guanfacine hydrochloride
tablets are contraindicated in patients with known hypersensitivity
to the drug.
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