A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Tenex Indications, Dosage, Storage, Stability - Guanfacine
Tenex Indications, Dosage, Storage, Stability - Guanfacine
INDICATIONS
Guanfacine hydrochloride
tablets are indicated in the management of hypertension. Guanfacine
should be given in combination with other antihypertensive agents,
especially thiazide-type diuretics.
DOSAGE AND ADMINISTRATION
The recommended initial
dose of guanfacine (as
the hydrochloride) when given in combination with another antihypertensive
drug is 1 mg
daily given at bedtime to minimize somnolence. If after 3 to 4 weeks
of therapy, 1 mg does not give a satisfactory result, a dose
of 2 mg may be given; although,
most of the effect of
guanfacine is seen at 1 mg
(see CLINICAL PHARMACOLOGY).
Higher daily doses have been used, but adverse reactions increase
significantly with doses above 3 mg/day .
According to JNC 7: the usual dose range is 0.5-2 mg once daily
The frequency of rebound
hypertension is
low, but it can occur. When rebound occurs, it does so after 2-4
days, which is delayed compared with clonidine hydrochloride. This
is consistent with the longer half-life
of guanfacine, In most cases,
after abrupt withdrawal
of guanfacine, blood pressure returns to pretreatment
levels slowly (within 2-4 days) without ill effects .
HOW SUPPLIED
Guanfacine hydrochloride
is available in 2 tablet
strengths of guanfacine (as the hydrochloride) as follows:
| Guanfacine Hydrochloride Tablets 1 mg, are pink, round
tablets, debossed with Watson 444 and are available in bottles
of: |
Guanfacine Hydrochloride Tablets 2 mg, are peach,
round tablets, debossed with Watson 453
and are available in bottles of: |
| 30, NDC 52544-444-30 |
30, NDC 52544-453-30 |
| 100, NDC 52544-444-01 |
100, NDC 52544-453-01 |
| 500, NDC 52544-444-05 |
500, NDC 52544-453-05 |
| 1000, NDC 2544-444-10 |
1000, NDC 52544-453-10 |
Bottles of 30 and 100 tablets are supplied with child-resistant
closures.
Store at controlled room
temperature 15-30°
C (59-86° F).
Dispense in tight, light-resistant container.
Rx only
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