A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Robinul Side Effects, and Drug Interactions - Glycopyrrolate
Robinul Side Effects, and Drug Interactions - Glycopyrrolate
SIDE EFFECTS
Anticholinergics produce certain effects, most of which are extensions
of their pharmacologic actions. Adverse reactions to anticholinergics
in general may include dry mouth: urinary hesitancy and retention;
blurred vision due to mydriasis; increased ocular
tension; tachycardia; palpitation; decreased sweating; loss
of taste; headache; nervousness; drowsiness; weakness; dizziness;
insomnia; nausea; vomiting; impotence; suppression
of lactation; constipation; bloated
feeling; severe allergic
reaction or drug
idiosyncrasies including anaphylaxis; urticaria
and other dermal manifestations; some degree of mental
confusion and/or excitement,
especially in elderly persons.
Glycopyrrolate is chemically a quaternary ammonium
compound; hence, its passage
across lipid membranes, such as the blood- brain
barrier is limited in
contrast to atropine
sulfate and scopolamine
hydrobromide. For this reason the occurrence of CNS
related side effects is
lower, in comparison to their incidence
following administration
of anticholinergics which are chemically tertiary amines that can
cross this barrier
readily.
DRUG INTERACTIONS
The intravenous
administration
of any anticholinergic
in the presence of cyclopropane
anesthesia can result
in ventricular arrhythmias;
therefore, caution should be observed if glycopyrrolate
injection is used
during cyclopropane anethesia. If the drug
is given in small incremental doses of 0.1 mg
or less, the likelihood of producing ventricular
arrhythmias is reduced.
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