A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Gleevec Online, Description, Chemistry, Ingredients - Imatinib Mesylate
Gleevec Online, Description, Chemistry, Ingredients - Imatinib Mesylate
DESCRIPTION
Gleevec® (imatinib mesylate) film-coated tablets
contain imatinib mesylate equivalent to 100 mg or 400 mg of imatinib free base.
Imatinib mesylate is designated chemically as 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)- 2-yrimidinyl]amino]-phenyl]benzamide
methanesulfonate and its structural formula is:
Imatinib mesylate is a white to off-white to brownish or yellowish
tinged crystalline powder. Its molecular formula is C29H31N7O
· CH4SO3 and its molecular
weight is 589.7.
Imatinib mesylate is soluble in aqueous buffers <
pH 5.5 but is very slightly soluble to insoluble in neutral/alkaline aqueous
buffers. In non-aqueous solvents, the drug substance is freely soluble to very
slightly soluble in dimethyl sulfoxide, methanol and ethanol, but is insoluble
in n-octanol, acetone and acetonitrile.
Inactive Ingredients
colloidal silicon dioxide (NF); crospovidone (NF); hydroxypropyl
methylcellulose (USP); magnesium stearate (NF); and microcrystalline cellulose
(NF). Tablet coating: ferric oxide, red (NF); ferric oxide, yellow (NF);
hydroxypropyl methylcellulose (USP); polyethylene glycol (NF) and talc (USP).
top
