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Geocillin Side Effects, and Drug Interactions - Carbenicillin Indanyl Sodium

Geocillin Side Effects, and Drug Interactions - Carbenicillin Indanyl Sodium

SIDE EFFECTS

The following adverse reactions have been reported as possibly related to Geocillin administration in controlled studies which include 344 patients receiving Geocillin.

Gastrointestinal: The most frequent adverse reactions associated with Geocillin therapy are related to the gastrointestinal tract. Nausea, bad taste, diarrhea, vomiting, flatulence, and glossitis were reported. Abdominal cramps, dry mouth, furry tongue, rectal bleeding, anorexia, and unspecified epigastric distress were rarely reported.

Dermatologic: Hypersensitivity reactions such as skin rash, urticaria, and less frequently pruritus.

Hematologic: As with other penicillins, anemia, thrombocytopenia, leukopenia, neutropenia, and eosinophilia have infrequently been observed. The clinical significance of these abnormalities is not known.

Miscellaneous: Other reactions rarely reported were hyperthermia, headache, itchy eyes, vaginitis, and loose stools.

Abnormalities of Hepatic Function Tests: Mild SGOT elevations have been observed following Geocillin administration.

DRUG INTERACTIONS

Geocillin (carbenicillin indanyl sodium) blood levels may be increased and prolonged by concurrent administration of probenecid.

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