A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Gantanol Side Effects, and Drug Interactions - Sulfamethoxazole
Gantanol Side Effects, and Drug Interactions - Sulfamethoxazole
SIDE EFFECTS
Included in the listing that follows are adverse reactions that have
not been reported with this specific drug; however, the pharmacologic
similarities among the sulfonamides require that each of the reactions
be considered with Gantanol administration.
Hematologic: Agranulocytosis, aplastic anemia, thrombocytopenia,
leukopenia, hemolytic anemia, purpura, hypoprothrombinemia, methemoglobinemia,
neutropenia, eosinophilia.
Allergic Reactions: Anaphylaxis, allergic myocarditis,
serum sickness, conjunctival and scleral injection, generalized allergic
reactions. In addition, periarteritis nodosa and systemic lupus erythematosus
have been reported.
Dermatologic: Stevens-Johnson syndrome, epidermal necrolysis,
erythema multiforme, exfoliative dermatitis, photosensitivity, pruritus,
urticaria, rash, generalized skin eruptions.
Gastrointestinal: Hepatitis, hepatocellular necrosis,
pseudomembranous enterocolitis, pancreatitis, stomatitis, glossitis, nausea,
emesis, abdominal pain, diarrhea, anorexia.
Genitourinary:Creatinine elevation, toxic nephrosis with
oliguria and anuria. The frequency of renal complications is considerably
lower in patients receiving the more soluble sulfonamides.
Neurologic: Convulsions, peripheral neuritis, ataxia, vertigo,
tinnitus, headache.
Psychiatric: Hallucinations, depression, apathy.
Endocrine: The sulfonamides bear certain chemical similarities
to some goitrogens, diuretics (acetazolamide and the thiazides) and oral
hypoglycemic agents. Cross-sensitivity may exist with these agents. Diuresis
and hypoglycemia have occurred rarely in patients receiving sulfonamides.
Musculoskeletal: Arthralgia, myalgia.
Respiratory: Pulmonary infiltrates.
Miscellaneous: Edema (including periorbital), pyrexia,
chills, weakness, fatigue, insomnia.
DRUG INTERACTIONS
In elderly patients concurrently receiving certain diuretics, primarily
thiazides, an increased incidence of thrombopenia with purpura has been
reported.
It has been reported that sulfamethoxazole may prolong the prothrombin
time in patients who are receiving the anticoagulant warfarin. This interaction
should be kept in mind when Gantanol is given to patients already on anticoagulant
therapy, and the coagulation time should be reassessed.
Sulfamethoxazole may inhibit the hepatic metabolism of phenytoin. At
a 1.6-g dose, sulfamethoxazole produced a slight but significant increase
in the half-life of phenytoin but did not produce a corresponding decrease
in the metabolic clearance rate. When administering these drugs concurrently,
one should be alert for possible excessive phenytoin effect.
Sulfonamides can also displace methotrexate from plasma protein-binding
sites, thus increasing free methotrexate concentrations.
The presence of sulfamethoxazole may interfere with the Jaffé alkaline
picrate reaction assay for creatinine, resulting in overestimations of
about 10% in the range of normal values.
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