A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Cerebyx Online, Description, Chemistry, Ingredients - Fosphenytoin
Cerebyx Online, Description, Chemistry, Ingredients - Fosphenytoin
DESCRIPTION
Cerebyx® (fosphenytoin sodium
injection) is a prodrug
intended for parenteral administration; its active metabolite
is phenytoin. Each Cerebyx vial contains 75 mg/mL fosphenytoin sodium
(hereafter referred to as fosphenytoin) equivalent to 50 mg/mL phenytoin
sodium after administration.
Cerebyx is supplied in vials as a ready-mixed solution
in Water for Injection, USP, and Tromethamine, USP (TRIS), buffer
adjusted to pH 8.6 to 9.0
with either Hydrochloric Acid, NF, or Sodium Hydroxide, NF. Cerebyx
is a clear, colorless to pale yellow, sterile
solution. The chemical
name of fosphenytoin is 5,5-diphenyl-3-[(phosphonooxy)methyl]-2,4-imidazolidinedione
disodium salt. The molecular weight
of fosphenytoin is 406.24. The molecular structure is:
IMPORTANT NOTE: Throughout all Cerebyx® product
labeling, the amount and concentration
of fosphenytoin is expressed in terms of phenytoin sodium equivalents
(PE). Fosphenytoin’s weight
is expressed as phenytoin sodium equivalents to avoid the need
to perform molecular weight-based adjustments when converting between
fosphenytoin and phenytoin
sodium doses. Cerebyx
should always be prescribed and dispensed in phenytoin
sodium equivalent units
(PE) (see DOSAGE AND ADMINISTRATION).
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